GURPS stands for “Generic Universal Role Playing System”. It tries and mostly succeeds in being a framework within which you can tell any kind of story in any kind of setting you like. It is a more complex rule set that shines when portraying normal to mildly exceptional people. It is one of my favorites and I’ve run horror, pirates, Three Musketeers and science fiction all using GURPS. If you have a setting that really interests you, likely there is a GURPS version of it.
Check out the amazing variety of GURPS material on their website!